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KMID : 0381120140360010031
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Genes and Genomics
2014 Volume.36 No. 1 p.31 ~ p.43
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Molecular-based identification and phylogeny of genomic and proteomic sequences of mosquito-borne flavivirus
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Gupta Sunil Kumar
Singh Sarita
Nischal Anuradha
Pant Kamlesh Kumar
Seth Prahlad Kishore
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Abstract
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Mosquito-borne flaviviruses (MBFVs) are important cause of emerging and re-emerging human diseases nearly worldwide, transmitted by arthropod vectors (mostly aedes and culex mosquitoes), with particular reference to yellow fever virus, Japanese encephalitis virus, dengue fever virus, St. Louis encephalitis virus, Murray Valley encephalitis virus, etc. In over 100 countries, more than 2.5 billion people are at risk of infection, and approximately 20 million infections are reported annually. Through the analysis of gene sequence data of these virus populations it is possible to infer phylogenetic relationships, which in turn can yield important epidemiological information, including their demographic history. Early attempts to define the evolutionary relationships and origins of viruses in the genus flavivirus are hampered by the lack of genetic information particularly amongst the MBFVs. In this study, complete genome, translated polyprotein, structural and non-structural proteins of MBFVs have been targeted and revealed an extensive series of clades defined by their epidemiology and disease associations. The branching patterns of at the deeper nodes of the resultant trees were different from those reported in the previous study. The significance of these observations is discussed.
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KEYWORD
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Mosquito-borne flavivirus, Phylogeny, Aedes-borne flavivirus, Culex-borne flavivirus, Virus transmission
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